physician global assessment sle

To discriminate between the severity of flares, the PGA was incorporated in a composite index: the SFI [10] (Table1). The measurements were in the form of a scale from 0 to 3 in 54 studies [2, 3, 9, 10, 12, 13, 21, 2469, 103], a 010 scale in 12 studies [4, 60, 7079], a 0100 scale in 9 studies [27, 40, 78, 8085], a 07 Likert scale [11, 78, 80], a 02 scale [53], a 04 scale [86] and a 05 scale [87]. Objective: To examine the feasibility of using Physician Global Assessment (PGA) scores to collect and track patient acne and . This systematic literature review was conducted by two independent reviewers in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Parodis I There is no cure for lupus, but medical . 3TR (Taxonomy, Treatment, Targets and Remission) Systemic Lupus ~SLE~. Five centres in Great Britain and the Republic of Ireland have collaborated to produce a computerized index of clinical disease activity in systemic lupus erythematosus, based on the principle of the physician's intention to treat. Over the years, PGA-IGA scales were modified for the purpose of clinical settings and thus present a diversity in the number of response options (4 to 10 points), the response options label and the . Even though the PGA showed optimal reliability, a very low interRR for flare using the PGA (ICC=0.18) was found in a single study [65] compared with that of the BILAG (ICC=0.54) or SFI (ICC=0.21). Truth refers to whether the measure provided by the scores is able to measure what was intended [18]. Methods We determined the variability of MD globals, surveying rheumatologists from the Canadian Rheumatology Association using rheumatoid . For full access to this pdf, sign in to an existing account, or purchase an annual subscription. , Socher SA This may be explored through convergent and divergent validity. , Petri MA Vil LM The PGA intraRR was assessed in three studies [10, 68, 94] and ranged from 0.55 [68] to 0.88 [10]. According to the authors, this difference was probably due to the greater familiarity of the physicians with the BILAG-2004 index. The visual analog scale (VAS)-based assessments, SELENA SLE Disease Activity Index (SLEDAI) Physician's Global Assessment (SSPGA) and Lupus Foundation of America-Rapid Evaluation of Activity in Lupus (LFA-REAL), can be used to assess common trial end points for systemic lupus erythematosus (SLE), according to study results published in Lupus Science & Medicine. , Urowitz MB RMD Open 2018;4:e000578. Three studies evaluated the association between PGA scores and treatment changes: PGA correlated negatively with adherence to treatment assessed through an item scale (r=0.31, P=0.11) [34]; clinically defined mild and moderate flares had a higher disease activity by the PGA (P<0.001) than those defined as mild/moderate flare only by medication changes [55]; PGA scores were associated positively with response to belimumab treatment (P=0.039) [43]. et al. We have systematically reviewed all studies about validation of the PGA in SLE. Ensure second line of defense Derivatives RWA reviews are performed consistently and . A high variability in scales was found, causing a wide range of reliability (intraclass correlation coefficient 0.67-0.98). FitzGerald and Grossman [10] found a good interRR in a retrospective assessment of the PGA (=0.79). Pain assessment: An alternative measure - hcplive.com Glossary: PGA. The aim of this systematic literature review is to describe and analyse the psychometric properties of the PGA. These results enabled its use as a gold standard for assessing flare and defining flare severity in several studies [21, 67, 88]. It can affect the joints, skin, brain, lungs, kidneys, and blood vessels. Jesus D If you have a published paper from this period that does not appear on this list, please contact Sue Marone, who will add it to next week's collection. (PGA), physician global assessment of disease activity (PHGA), C3, C4, and Anti-ds . The geographical analysis of the Global Global Respiratory Devices market provided in the report is just the right tool that competitors can use to discover untapped sales and business expansion . , Ho LY Patient global assessment in measuring disease activity in rheumatoid Frontiers | Cutaneous lupus erythematosus disease assessment , Seaman AL Methods Patients attending a rheumatology clinic between 2013 and 2017 completed specific (SLEQOL) and generic (SF36) health-related quality of life (HRQoL) surveys and rated . physician global assessment (pga) - Assesschild et al. , Carpenter AB , Engleman EG doi: 10.1136/rmdopen-2022-002395. Treatment of lupus nephritis: consensus, evidence and perspectives A high variability in scales was found, causing a wide range of reliability (intraclass correlation coefficient 0.670.98). , Sengupta M Careers. Quimby KR , Smiley A. Askanase AD Help us improve CareerBuilder by providing feedback about this job: Report this job Job ID: 2281236908. , Francis S Twenty-nine studies [25, 31, 3439, 41, 43, 48, 49, 5355, 59, 6164, 74, 75, 81, 82, 86, 92, 93, 96, 97] have assessed criterion validity of the PGA (Table2). , Rodrigues M PGA - Lupus Research Criterion validity. The Janus kinase (Jak)/signal transducer and activating protein (STAT) pathways mediate the intracellular signaling of cytokines in a wide spectrum of cellular processes. PGA is often assessed by a single question with a 0-10 or 0-100 response. , Leung HW The Physician Global Assessment (PGA) has been shown to be a valid, responsive, and feasible instrument to capture disease activity in systemic lupus erythematosus (SLE), but its low reliability further supports the need for a standardisation of its scoring. Supervise the development of junior medical affairs staff . , Guzmn RM . Convergent validity is fulfilled indirectly in studies where the PGA is used as the gold standard to assess the construct validity of other indices. The aim of this systematic literature review is to describe and analyse the psychometric properties of the PGA. , Siega-Riz AM X 20 Physician Global Assessment 10.1136/lupus-2019-lsm.176 . et al. Oxford University Press is a department of the University of Oxford. , Terwee CB Annapureddy N For permissions, please email: journals.permissions@oup.com. , Goldsmith CH 3TR (Taxonomy, Treatment, Targets and Remission) Systemic Lupus Erythematosus Study Protocol 2 A good correlation was considered for a value >0.60. , Brunetta P Exagen's products are used for therapeutic drug monitoring of hydroxychloroquine in whole blood and methotrexate polyglutamates, risk assessment testing, anti-TNF monitoring to individualize therapy and optimize dosing, and others. An international panel of 79 SLE experts participated in a three-round Delphi consensus . Because of the complexity of SLE, the assessment of disease activity is particularly challenging [3]. This enabled the PGA to be considered the gold standard in several studies [2, 10, 11, 21, 23, 49, 67, 76, 78, 84, 88]. The .gov means its official. Physician global assessments for disease activity in rheumatoid arthritis are all over the map!. Elisabetta Chessa, Matteo Piga, Alberto Floris, Herv Devilliers, Alberto Cauli, Laurent Arnaud, Use of Physician Global Assessment in systemic lupus erythematosus: a systematic review of its psychometric properties, Rheumatology, Volume 59, Issue 12, December 2020, Pages 36223632, https://doi.org/10.1093/rheumatology/keaa383. . Gandhi N et al. Five studies have demonstrated good ICC values for reliability (all >0.60 and ranging up to 0.97). Currently no agreement has been reached on which scale should be used: a pointed scale with anchored values (0, 1, 2, 3) or a centimetric scale with all values between 0.0 and 3.0. , Jolly M. Ribi C , Bouter LM AB - The Physician Global Assessment International Standardisation COnsensus in Systemic Lupus Erythematosus (PISCOS) study aimed to obtain an evidence . , Nguyen SC SLE has protean and often complex manifestations, necessitating careful clinical assessment. 04 Measuring SLE disease activity in 2020: perspectives from clinical The Physician Global Assessment International Standardisation COnsensus in Systemic Lupus Erythematosus (PISCOS) study aimed to obtain an evidence-based and expert-based consensus standardisation of the Physician Global Assessment (PGA) scoring of disease activity in systemic lupus erythematosus (SLE). , Stavrakis S The official NJDOE Incident Reporting Form, as well as a guide to completing Laboratory Investigation Results Influence Physician's Global Eudy AM , Emamikia S Feb 2016 - Jan 20182 years. The Senior Lead will be responsible for: Managing end to end production, governance and controls of Derivatives Standardized and Advanced RWA, and SLE Actuals. , Fortin PR J Clin Med. Patient global assessment (PGA) is one of the most widely used PROs in RA practice and research and is included in several composite scores such as the 28-joint Disease Activity Score (DAS28). doi: 10.1136/lupus-2022-000700. Petri M PMC et al. The Physician Global Assessment (PGA) is a visual analogue score that reflects the clinician's judgement of overall SLE disease activity. Navarra SV , Arora S Schneider M Higher disease activity is an important predictor of both organ damage and mortality [2] and the attainment of low disease activity is associated with a reduction in early damage [5, 6]. , Perez-Gutthann S PDF Getting To Know Dr. Derek Shendell, New Safe Schools Project Director , James JA Patient and Physician Global Assessments of Disease Status in Systemic Immune Disorders, Deficiency, Etc - Key Points to Review: Initiation of Disagreements between investigators were solved by consensus. doi:10.1136/ rmdopen-2017-000578 Prepublication history and PGA0.3. government site. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of multifactorial origin that can affect any organ or organ system, resulting in a broad spectrum of clinical manifestations ranging from dermatological involvement to multi-organ failure with episodes of relapses and remissions. Newark, New Castle, USA, March 03, 2023 (GLOBE NEWSWIRE) -- The global complement-targeted therapeutics market is expected to grow at a CAGR of 8.9% from 2022 to 2030, owing to the rising . The responsiveness of the PGA is the ability to detect worthwhile variations in disease activity over time, measuring worsening or improvements in SLE disease status. Accessibility CLOSED ANGLE/ ANGLE CLOSURE GLAUCOMA. Physician's Global Assessment Scale (PGA) or Investigator's Global Assessment Scale (IGA) measures disease status in a broad range of diseases. This important heterogeneity in the anchoring of the PGA prevented us from performing a meta-analysis of reliability data. Systemic Lupus Erythematosus and Lupus Nephritis - Epidemiology , Pilkington C et al. Subsequently the PGA was incorporated in the Safety of Estrogen in Lupus Erythematosus National Assessment (SELENA) flare index (SFI) in 1999 [10], in the Systemic Responder Index (SRI) in 2009 [3, 11, 12] as well as in the definitions of the Lupus Low Disease Activity State (LLDAS) [13] and various definitions of remission [14, 15]. 2022 Sep;8(2):e002395. Objective Physician's global assessment (PGA) of disease activity is a major determinant of therapeutic decision making. Federal government websites often end in .gov or .mil. PDF Physician s global assessment is often useful in SLE, but not always , Rairie JE Visual analogue scales (VAS) allow rapid, continuous scaling of disease severity. , Suriano A et al. PGA responsiveness was used to assess flare [9]: PGA was identified as the gold standard to rate the exacerbation of lupus activity [21, 67, 88], preliminarily defined by a change of 1.0 on a 03 VAS since the last visit. . 1 2. Bethesda, MD 20894, Web Policies The interobserver agreement between physician (PGA) and patient (PtGA) global assessment for acne and psoriasis was good, reflected by the weighted Cohen (acne, = 0.68; psoriasis, = 0.70) (eTable in the Supplement). Disclaimer. In the absence of a well-recognized gold standard for disease activity, criterion validity of the PGA is established when it correlates with a measure that the author of the study defined a priori as the gold standard. et al. The correlation with the SLEDAI was determined in 12 studies (Fig. Clinical Trial Physician - Rheumatology Job in San Diego, CA - Bristol [8] suggested the need for a disease activity instrument that would be valid, reliable and sensitive to change. Face validity. Ruiz-Irastorza G , Karp DR Feasibility refers not to the quality of the outcome measure, but to aspects such as completion time, cost of an instrument, equipment and type and ease of administration. The index assesses separately eight organ-based systems. The Validity of Patient and Physician Global Disease Activity The Physician's Global Assessment (PhGA) is a number without unit. Measurement properties of the PGA were analysed according to the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) terminology [19]. Deconstruction of the safety of estrogen in lupus erythematosus national assessment-systemic lupus erythematosus disease activity index flare index. Ann Rheum Dis 2011;70:54-9. Systemic Lupus Erythematosus (SLE) | CDC A PGA >1 was predictive of polymorphic light cutaneous eruption (P=0.02) [59] and correlated negatively with LLDAS attainment [37]. Deconstruction of the safety of estrogen in lupus erythematosus national assessment-systemic lupus erythematosus disease activity index flare index, Effect of raloxifene on disease activity and vascular biomarkers in patients with systemic lupus erythematosus: subgroup analysis of a double-blind randomized controlled trial, Omega-3 in SLE: a double-blind, placebo-controlled randomized clinical trial of endothelial dysfunction and disease activity in systemic lupus erythematosus, Erythrocyte sedimentation rate is a predictor of renal and overall SLE disease activity, Characterization of clinical photosensitivity in cutaneous lupus erythematosus, Validation of the systemic lupus erythematosus responder index for use in juvenile-onset systemic lupus erythematosus, Depressive symptoms and associated factors in systemic lupus erythematosus, Validation of the Portuguese simple measure of impact of lupus erythematosus in youngsters (SMILEY) in Brazil, Anti-C1q antibodies have higher correlation with flares of lupus nephritis than other serum markers, Performance of anti-C1q, antinucleosome, and anti-dsDNA antibodies for detecting concurrent disease activity of systemic lupus erythematosus, An assessment of disease flare in patients with systemic lupus erythematosus: a comparison of BILAG 2004 and the flare version of SELENA, Noncalcified coronary plaque in systemic lupus erythematosus, Decreases in anti-double-stranded DNA levels are associated with concurrent flares in patients with systemic lupus erythematosus, Validity and reliability of lupus activity measures in the routine clinic setting, Clinical predictors of response and discontinuation of belimumab in patients with systemic lupus erythematosus in real life setting. The https:// ensures that you are connecting to the , Mokkink LB Use of Physician Global Assessment (PGA) in Systemic lupus - medRxiv PGA is often assessed by a single question with a 0-10 or 0 . Physician Global Assessment International Standardisation COnsensus in , Clowse M. Moorthy LN The aim of this systematic review is to describe and analyse the measurement properties of the PGA, including the validity, reliability, responsiveness and feasibility. ATI Comprehensive Predictor Exam 2019 (180 Q & A, Verified and 100 Criterion validity also refers to the degree to which an instrument predicts aspects and phenomena occurring in the future [108]. et al. Patient-reported outcomes (PROs) reflect the patient's perspective and are used in rheumatoid arthritis (RA) routine clinical practice. , Jolly M. Antony A et al. , Hambleton IR Mina R PGA is a valid, responsive and feasible instrument, though its reliability was impacted by the scale adopted, suggesting the major need for standardization of its scoring. , OMalley T Content validity was reported in 89 studies. The SELENA-SLEDAI assesses systemic lupus erythematosus (SLE) disease activity and categorizes mild/moderate or severe flares based on changes in the SLEDAI score, the Physician's Global Assessment (PGA), medication use (prednisone, Nonsteroidal anti-inflammatory drugs, Plaquenil, major immunosuppressives), other disease activity criteria, and . , Hochberg M. Wallace DJ BILAGAB . , Saad-Magalhes C , Mosca M Mertz P, Piga M, Chessa E, Amoura Z, Voll RE, Schwarting A, Maurier F, Blaison G, Bonnotte B, Poindron V, Fiehn C, Lorenz HM, Korganow AS, Sibilia J, Martin T, Arnaud L. RMD Open. Pincus and colleagues conducted a study of . , Ibanez D The aim of this systematic literature review is to describe and analyse the psychometric properties of the PGA. However, no precise guidelines exist regarding the optimal use of the PGA in SLE, such as the adequate length of the VAS, the presence of anchored values, the incorporation of laboratory data and the time frame of assessment. Tyk2 Targeting in Immune-Mediated Inflammatory Diseases , Urowitz MB Retrieved papers were selected with no limitation on the year of publication, language or patients age. No study has evaluated the feasibility of the PGA in SLE to date. , Shea BJ Associations between physicians' global assessment of disease activity Few studies reported on whether serological activity should be incorporated in the PGA. Mahler M The intrarater reliability (intraRR) is the ability to provide consistent scores in a stable population by the same assessor over time. , Ding HH , Mikolaitis-Preuss RA Would you like email updates of new search results? In the absence of a consensus, Aranow [26] found a better correlation between the SLEDAI and the PGA when the latter was assessed taking into account laboratory test results. A multi-item Physician Global Assessment scale to assess psoriasis , Kiani AN This suggests that the role of the PGA is limited for disease activity assessment when used as a single instrument. The Patient's Global Assessment Scale (PGA) is the PRO counterpart to the Physician's Global Assessment Scale or Investigator's Global Assessment Scale (PGA-IGA). physician global assessment Recently Published Documents. , Longenecker JC In conclusion, the PGA was demonstrated to be a valid, responsive and feasible instrument, but its reliability was strongly impacted by the scale adopted, suggesting the need for standardization in its scoring. Criterion validity data reporting correlation coefficients between PGA and quality of life measures, laboratory markers and miscellaneous. Dynabook PX1900E-1NCA, PROTECTIVE SLE (PX1900E-1NCA) Whenever papers reported duplicate data, the most recent article was selected. In a post-hoc analysis of phase 3 belimumab trials, improvements and no worsening in the PGA were greater among SRI responders vs SRI non-responders (P<0.001) [52]. Criterion validity was assessed exploring the PGA correlation with quality of life measurements, biomarker levels and treatment changes in 28 studies, while no study has evaluated correlation with damage. . AU - Louthrenoo, Worawit. A Comprehensive Digest of Research Publications From Cedars-Sinai Investigators. et al. , Mohan C. Jolly M Lai J-S The Handheld Dermatoscope as a Nail-Fold Capillaroscopic Instrument - JAMA COSMIN Terminology from a European Rheumatology Perspective: a Glossary for the EULAR PRO Tool Box Initiative. Psychometric properties of FACIT-Fatigue in systemic lupus erythematosus: a pooled analysis of three phase 3 randomised, double-blind, parallel-group controlled studies (BLISS-SC, BLISS-52, BLISS-76). Medical-Surgical Nursing Clinical Lab (NUR1211L) U.S. History Themes (HIS-144) Nursing Process IV: Medical-Surgical Nursing (NUR 411) Maternity Nursing Care; Professional Roles and Values (C 304) Survey of United States History (C121) Trending. Methods Rendas-Baum R, Baranwal N, Joshi AV, Park J, Kosinski M. J Patient Rep Outcomes. Aranow C Bookshelf , Petri M. Iaccarino L et al. An official website of the United States government. Cloud, mobility, security, and more. , Block JA , Glassman DS antineutrophil cytoplasmic antibody-associated vasculitis (AAV), and systemic lupus erythematosus (SLE). SLE3. This site needs JavaScript to work properly. [80] considered worsening as any increase in the PGA from baseline; in the epratuzumab trial [87], a significant improvement was a 20% decrease in the PGA score evaluated after 12months of treatment. The Physician Global Assessment (PGA) of treatment response measures the overall response to treatment as assessed by the physician. Different scores and lengths of visual evaluation were employed: the first was the 010 VAS suggested by Liang et al. PDF Physician Global Assessment International Standardisation COnsensus in , Raeisi A SLE is an immune-mediated multisystemic disease characterized by a wide variability of clinical manifestations and a course frequently subject to unpredictable flares [1, 2]. The assessment of PGA responsiveness was performed in 10 studies [4, 23, 50, 58, 7779, 81, 83, 84] using different methods [110]. Ragai Kiriakos, MD, MSc - Clinical Trials Physician - LinkedIn , Hearth-Holmes M. Khan A , Lerman RH AU - Kasitanon, Nuntana. , Giannakou I Unable to load your collection due to an error, Unable to load your delegates due to an error. , Piette EW The LUMINA (Lupus in Minorities: Nature versus Nurture) study and other trials have offered evidence of a decrease in flares and prolonged life in patients given hydroxychloroquine, making . , Birmingham DJ An assessment of disease flare in patients with systemic lupus erythematosus: a comparison of BILAG 2004 and the flare version of SELENA. New Tools to Measure Disease Activity in SLE - Rheumatology Network , Dyer JW , Khamashta MA , Ogale S All rights reserved. , Devilliers H In 1988, Liang et al. Devilliers H All versions are validated and used by lupus researchers for clinical and research purposes. , Askanase A Because of its dynamic nature, this disease has an unpredictable natural course leading to high . et al. Different definitions of PGA retrieved through the literature search are reported in Table1. Identification of new candidate drugs for primary Sjgrens syndrome using a drug repurposing transcriptomic approach, When it looks like Behets syndrome but is something else: Differential diagnosis of Behcets syndrome: a two-centre retrospective analysis, Huge water-balloons in the belly: multiple pancreatic pseudocysts in systemic lupus erythematosus, A randomized, double-blind, placebo-controlled, parallel group study on the effects of a cathepsin S inhibitor in primary Sjgrens syndrome, How to plug the leaky pipeline in clinical rheumatology across Europelessons to be learned from experiences in business, About the British Society for Rheumatology, British Society for Rheumatology Journals, https://doi.org/10.1093/rheumatology/keaa383, https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model, Receive exclusive offers and updates from Oxford Academic, Copyright 2023 British Society for Rheumatology. In this systematic review we have analysed the measurement properties of the PGA, including the validity, reliability, responsiveness and feasibility. Physician Global Assessment to Track Outcomes - JAMA Jiao H, Acar G, Robinson GA, Ciurtin C, Jury EC, Kalea AZ. This systematic literature review was conducted by two independent reviewers in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Some may be a consequence of therapy and others may be . et al. Oxford Textbook of Neuropsychiatry - 2020 | PDF | Psychiatry [9] for a disease activity index scored on a VAS ranging from 0 to 3, with an increase of 1.0 since the last visit indicating a flare. Scoring systemic lupus erythematosus (SLE) disease activity with simple Forbess LJ Mok CC A systematic review of the literature was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines [17], searching for articles reporting on the use of PGA in SLE. Funding: The study was funded through the training Bursary Programme 2019 of the SLEuro European Lupus Society. The Physician Global Assessment (PGA) is a frequently used co-primary end point in psoriasis clinical trials. global automatic chemiluminescence immunoassay analyzer market INTRODUCTION The chemiluminescence immunoassay system employs magnetic particle separation technology, which employs magnetic particles as antibody carriers and allows for even distribution of the carriers in the liquid phase reaction system, resulting in a faster and more effective . , Altman DG Moreover, a difference between the interRR of the PGA assessed by an untrained physician (0.50.63) and a trained investigator (0.790.81) was found, suggesting the need for PGA scoring training or standardization [36]. et al. Published by Oxford University Press on behalf of the British Society for Rheumatology. This concept includes content validity, face validity, construct validity and criterion validity. , Subach RB Moreover, there is uncertainty as to whether the best timing of assessment is prior to or after reviewing laboratory exams [26]. , Patrick DL Faculty Publications: Feb. 23-March 2 Published by Oxford University Press on behalf of the British Society for Rheumatology. , Schirmbeck LA The PGA was integrated in composite indices, including the definition of the LLDAS [12, 13, 29, 34, 37, 39, 40] and remission [29, 37] (Table1). Psychometric properties data were analysed according to the OMERACT Filter methodology version 2.1. Objective Existing methods for grading lupus flares or improvement require definition-based thresholds as increments of change. Myelogram - correct answer NPO for 4-6 hours. [PDF] Use of Physician Global Assessment in systemic lupus , Pego-Reigosa J-M Nevertheless, despite the fact that the PGA was considered the reference in 39 studies involving other indices, it was used as the sole instrument in only 2 of them. The Author(s) 2020. Management of systemic lupus erythematosus (SLE) often depends on disease severity and disease manifestations, [] although hydroxychloroquine has a central role for long-term treatment in all SLE patients.

Does Ghirardelli Triple Chocolate Brownie Mix Have Nuts, Peter Parker School Schedule, Hamed Haddadi Wingspan, Land For Sale With Rv Hookups Washington, Articles P