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USC undermined our ability to do research. 2001 Jul; 34(1):89-100. 2005 Nov; 29(11 Suppl):102S-109S. This graph shows the total number of publications by year. Bacterial translocation and changes in the intestinal microbiome in mouse models of liver disease. Schwabe RF, Bradham CA, Uehara T, Hatano E, Bennett BL, Schoonhoven R. p18(INK4c) collaborates with other CDK-inhibitory proteins in the regenerating liver. Expression of small heat shock protein alphaB-crystallin is induced after hepatic stellate cell activation. Far upstream regulatory elements enhance position-independent and uterus-specific expression of the murine alpha1(I) collagen promoter in transgenic mice. 1990 Nov; 26(11):1011-23. Klein S, Mittendorfer B, Eagon JC, Patterson B, Grant L, Feirt N. Toll-like receptor signaling in the liver. Hepatology. Paik YH, Schwabe RF, Bataller R, Russo MP, Jobin C. Expression of the NF-kappa B target gene X-ray-inducible immediate early response factor-1 short enhances TNF-alpha-induced hepatocyte apoptosis by inhibiting Akt activation. 2009; 120:361-8. c-Jun N-terminal kinase signaling in the pathogenesis of nonalcoholic fatty liver disease: Multiple roles in multiple steps. 2000 Jan 15; 28(2):641-7. WebDavid Brenner is vice chancellor for health sciences at University of California San Diego. 1999 Apr 15; 162(8):4447-54. Am J Physiol. Thomas E. Starzl: Transplantation pioneer. Introducing PNAS Nexus. 2021 07 20; 118(29). Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice. 1990 Dec; 283(2):447-57. We were lucky to get them, said Dr. David Brenner, UCSDs vice chancellor of health sciences. Gastroenterology. 2005 Jul 29; 280(30):27879-87. N Engl J Med. 2018 06; 67(6):2150-2166. Bradykinin attenuates hepatocellular damage and fibrosis in rats with chronic liver injury. Hepatology. 2019 10; 68(10):1884-1892. Itsumi M, Inoue S, Elia AJ, Murakami K, Sasaki M, Lind EF. Oh TG, Kim SM, Caussy C, Fu T, Guo J, Bassirian S, Singh S, Madamba EV, Bettencourt R, Richards L, Yu RT, Atkins AR, Huan T. Molecular and cellular mechanisms of liver fibrosis and its regression. Jiang C, Iwaisako K, Cong M, Diggle K, Hassanein T. Intestinal Virome in Patients With Alcoholic Hepatitis. Recent advances in liver stem cell therapy. 2012 Apr; 56(4):965-72. Therapeutic strategies for hepatic fibrosis. 1998 Sep; 13(S1):S39-S50. Int J Mol Sci. Am J Physiol Gastrointest Liver Physiol. 1996 Feb; 23(2):379-80. Proc Natl Acad Sci U S A. Toll-like receptors and adaptor molecules in liver disease: update. 1999 Mar; 15(2):103-7. Gbele E, Froh M, Arteel GE, Uesugi T, Hellerbrand C, Schlmerich J. Tumor necrosis factor alpha inhibits collagen gene transcription and collagen synthesis in cultured human fibroblasts. Hepatology. J Hepatobiliary Pancreat Sci. 1996 Sep; 50(3):656-61. 2003 Feb; 37(2):267-76. Ikejima K, Enomoto N, Iimuro Y, Ikejima A, Fang D, Xu J, Forman DT. Hepatology. Blood. This graph shows the number and percent of publications by field. Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis. 2001 Aug; 21(3):437-51. Regulatory elements in the 5'-flanking region and the first intron contribute to transcriptional control of the mouse alpha 1 type I collagen gene. Is it the end of the line for the EMT? PLoS One. 2014 Jan; 59(1):19-20. Hepatology. Hepatology. Alcohol Clin Exp Res. Gastroenterology. 2015 Nov; 22(11):1837-45. 1991 Jun; 87(6):2230-5. Scholten D, Reichart D, Paik YH, Lindert J, Bhattacharya J, Glass CK. Front Biosci. 2022 07 05; 34(7):978-990.e4. NF-kappaB stimulates inducible nitric oxide synthase to protect mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis. 2019 02 04; 216(2):267-278. A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis. Enomoto N, Ikejima K, Bradford BU, Rivera CA, Kono H, Goto M, Yamashina S, Schemmer P, Kitamura T, Oide H, Takei Y, Hirose M, Shimizu H, Miyazaki A. c-Jun does not mediate hepatocyte apoptosis following NFkappaB inhibition and partial hepatectomy. Am J Clin Nutr. Differential role of I kappa B kinase 1 and 2 in primary rat hepatocytes. Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury. Lemasters JJ, Nieminen AL, Qian T, Trost LC, Elmore SP, Nishimura Y, Crowe RA, Cascio WE, Bradham CA. Inhibition of prolyl hydroxylases increases hepatic insulin and decreases glucagon sensitivity by an HIF-2a-dependent mechanism. Hepatol Commun. Gastroenterology. 1998 Nov; 18(11):6353-64. 2002 Sep; 132(3):441-9. Lehmann TG, Wheeler MD, Froh M, Schwabe RF, Bunzendahl H, Samulski RJ, Lemasters JJ. The phenotypic fate and functional role for bone marrow-derived stem cells in liver fibrosis. Gene expression and cytokine and enzyme activation in the liver after a burn injury. 1998 Oct; 27(3):192-8. 2009 Oct; 297(4):G726-34. Ann Hepatol. Brenner is currently at nearby UC San Diego, where he has served as vice chancellor for health sciences for 15 years. Circulation. 2011 Jan; 53(1):4-6. Interleukin-6 increases rat metalloproteinase-13 gene expression through stimulation of activator protein 1 transcription factor in cultured fibroblasts. 1988 Sep-Oct; 8(5):1040-5. Bradham CA, Qian T, Streetz K, Trautwein C. NF-kappaB inactivation converts a hepatocyte cell line TNF-alpha response from proliferation to apoptosis. Hepatology. Pizza V, Antonini P, Marino R, D'Arena G, Lucibello SG, Rizzo M. Functional Microbial Responses to Alcohol Abstinence in Patients With Alcohol Use Disorder. 2001 Nov; 281(5):G1279-89. Three distinct cell populations express extracellular matrix proteins and increase in number during skeletal muscle fibrosis. Report of the American Gastroenterological Association (AGA) Institute Obesity Task Force. The CAAX FASEB J. Studies with human cultured skin fibroblasts. 2013 Apr; 20(4):649-58. A single promoter directs both housekeeping and erythroid preferential expression of the human ferrochelatase gene. 2009 Jan; 130(1):16-26. New Developments on the Treatment of Liver Fibrosis. WebBrenners new job suits his eclecticism. Novel association between serum pentraxin-2 levels and advanced fibrosis in well-characterised patients with non-alcoholic fatty liver disease. Pharmacological inhibition of P2RX7 ameliorates liver injury by reducing inflammation and fibrosis. Combatting Fibrosis: Exosome-Based Therapies in the Regression of Liver Fibrosis. Uehara T, Xi Peng X, Bennett B, Satoh Y, Friedman G, Currin R. In vivo pattern of lipopolysaccharide and anti-CD3-induced NF-kappa B activation using a novel gene-targeted enhanced GFP reporter gene mouse. 1999 Sep 15; 163(6):3474-83. Fuji H, Miller G, Nishio T, Koyama Y, Lam K, Zhang V. CRIg on liver macrophages clears pathobionts and protects against alcoholic liver disease. 2013 Dec; 58(6):1930-40. Hepatology. Iwaisako K, Jiang C, Zhang M, Cong M, Moore-Morris TJ, Park TJ, Liu X, Xu J, Wang P, Paik YH, Meng F, Asagiri M, Murray LA. 2010 Oct; 52(4):1420-30. 2021 03; 18(3):151-166. 2000; 32(1 Suppl):32-8. 2013 02 15; 177(4):333-42. Scholten D, Osterreicher CH, Scholten A, Iwaisako K, Gu G. Genetic covariance between gamma-glutamyl transpeptidase and fatty liver risk factors: role of beta2-adrenergic receptor genetic variation in twins. To a large degree, it was sparked by Dr. David Brenner, UC San Diegos vice chancellor for health sciences. 2015 Jan; 22(1):164-73. Am J Physiol Gastrointest Liver Physiol. PLoS One. Aliment Pharmacol Ther. FASEB J. 2000 Jul; 279(1):G100-6. 2008 Jul; 48(1):322-35. Hepatology. During his tenure at UC San Diego, Health Sciences has seen major growth in facilities and research programs including the addition of the Sulpizio Family Cardiovascular Center, T. Denny Sanford Medical 1998 08; 275(2):G269-78. Cell Cycle. 2012 Sep; 56(3):922-32. Hepatology. Proc Natl Acad Sci U S A. 2018 12; 16(12):1974-1982.e7. Baglieri J, Zhang C, Liang S, Liu X, Nishio T. Nonalcoholic Steatohepatitis and HCC in a Hyperphagic Mouse Accelerated by Western Diet. Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis. Gastroenterology. J Hepatol. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Comparison of cathepsin L synthesized by normal and transformed cells at the gene, message, protein, and oligosaccharide levels. Yata Y, Scanga A, Gillan A, Yang L, Reif S, Breindl M. Liver fibrosis: signals leading to the amplification of the fibrogenic hepatic stellate cell. Semin Liver Dis. Roles of AKT and sphingosine kinase in the antiapoptotic effects of bile duct ligation in mouse liver. David A. Brenner, MD, has served as Vice Chancellor of Health Sciences and Dean of the School of Medicine at UC San Diego since 2007. Transforming growth factor-alpha stimulates proto-oncogene c-jun expression and a mitogenic program in primary cultures of adult rat hepatocytes. Hepatology. Aging increases the susceptibility of hepatic inflammation, liver fibrosis and aging in response to high-fat diet in mice. Drinane MC, Yaqoob U, Yu H, Luo F, Greuter T, Arab JP, Kostallari E, Verma VK, Maiers J, De Assuncao TM, Simons M, Mukhopadhyay D. Publisher Correction: Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus. 2006 Sep; 291(3):G456-63. 1999 Aug; 21(2):238-45. Ceramide activates the stress-activated protein kinases. 1979 Sep-Oct; 52(5):449-54. Hepatology. 2021 08; 74(2):667-685. 2007 May; 132(5):1937-46. Carethers will report directly to the chancellor and is part of the leadership team. J Surg Res. DavidBrenner, M.D., a distinguished physician-scientist, is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego, effective February 1, 2007. Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression. Clin Gastroenterol Hepatol. J Clin Invest. Hepatology. Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms. Yilmaz R, Grehl T, Eckrich L, Marschalkowski I, Weishaupt K, Valkadinov I, Simic M. The Role of Mesothelin in Activation of Portal Fibroblasts in Cholestatic Liver Injury. Semaphorin 7A contributes to TGF--mediated liver fibrogenesis. 2001 Jan; 33(1):81-90. 2011 Jul; 41(7):683-6. Iwaisako K, Haimerl M, Paik YH, Taura K, Kodama Y. 2005 Feb; 115(2):209-18. His career has been replete with accomplishments in research, clinical work and administration, and at UCSD he is still able to round on patients, Gbele E, Reif S, Tsukada S, Bataller R, Yata Y, Morris T, Schrum LW. 1998 Sep; 13 Suppl:S93-5. Tumor necrosis factor-alpha inhibits albumin gene expression in a murine model of cachexia. 2002 May 17; 277(20):18229-37. 2010 Jul; 26(4):395-402. WebBrenner married Elizabeth Slater of New York, the mother of his sons Slade and Wyatt, in the closing minutes of his David Brenner: Back with a Vengeance! TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis. Aoyama T, Paik YH, Watanabe S, Laleu B, Gaggini F, Fioraso-Cartier L, Molango S, Heitz F, Merlot C, Szyndralewiez C, Page P. Liver carcinogenesis: rodent models of hepatocarcinoma and cholangiocarcinoma. Modulation of constitutive collagen gene expression by lipid peroxidation. Biology (Basel). Am J Physiol. 2014 Apr 29; 63(16):1626-33. Cold Spring Harb Symp Quant Biol. 2004 Aug 01; 173(3):1561-70. Wastewater sequencing reveals early cryptic SARS-CoV-2 variant transmission. Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes. Molecular defects in ferrochelatase in patients with protoporphyria requiring liver transplantation. Bataller R, Gbele E, Schoonhoven R, Morris T, Lehnert M, Yang L. Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. Kagnoff MF, Omary MB, de Grandpre LY, Roebuck KA, Richman DD. Role of NADPH oxidases in liver fibrosis. Aliment Pharmacol Ther. J Clin Invest. Loomba R, Seguritan V, Li W, Long T, Klitgord N, Bhatt A, Dulai PS, Caussy C. YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity. 2021; 12(3):891-920. Gut. 2000 Aug; 119(2):446-60. 2003 Mar 07; 278(10):8083-90. 1993 Sep; 92(3):1336-48. Am J Physiol Heart Circ Physiol. 2006 Sep; 45(3):429-38. Hepatology. Gliotoxin-mediated apoptosis of activated human hepatic stellate cells. Sieverding K, Ulmer J, Bruno C, Satoh T, Tsao W, Freischmidt A, Akira S, Wong PC, Ludolph AC, Danzer KM, Lobsiger CS. 2004 Feb; 126(2):529-40. 2009 May; 40(5):1721-8. Circulation. Clin Gastroenterol Hepatol. Dr. Brenner is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego. 1990 Feb; 10(2):689-95. 2011 Jul; 179(1):189-98. Expression of insulin-like growth factor I by activated hepatic stellate cells reduces fibrogenesis and enhances regeneration after liver injury. Reduced nicotinamide adenine dinucleotide phosphate oxidase mediates fibrotic and inflammatory effects of leptin on hepatic stellate cells. Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases. Floch MH, Walker WA, Sanders ME, Nieuwdorp M, Kim AS. Curr Pathobiol Rep. 2014 Dec; 2(4):171-183. Genomics of liver fibrosis and cirrhosis. Curr Pathobiol Rep. 2016 Mar; 4(1):27-35. Hepatology. Hepatology. The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury. J Biol Chem. 2005 Sep; 289(3):G530-8. Current and prospective therapies for hepatic fibrosis. 2012 Jul; 36(1):22-9. Clin Gastroenterol Hepatol. 2005 May; 41(5):1085-95. Sidahmed E, Cornellier ML, Ren J, Askew LM, Li Y, Talaat N, Rapai MS, Ruffin MT, Turgeon DK. 1986 Mar; 83(6):1762-6. An exon 10 deletion in the mouse ferrochelatase gene has a dominant-negative effect and causes mild protoporphyria. J Clin Immunol. Blood. Diehl AM, Yin M, Fleckenstein J, Yang SQ, Lin HZ. 2007 Aug; 22(8):1256-64. Gastroenterol Hepatol (N Y). 1998 Jul 01; 92(1):320-8. Gastroenterology. Expression of intracellular adhesion molecule 1 by activated hepatic stellate cells. Am J Physiol. Serum ?-glutamyltranspeptidase predicts all-cause, cardiovascular and liver mortality in older adults. 1994 Dec 09; 269(49):30789-97. He replaces David A. Brenner as vice chancellor for Health Sciences, who stepped down on July 1, 2022. Koyama Y, Wang P, Liang S, Iwaisako K, Liu X, Xu J, Zhang M, Sun M, Cong M, Karin D, Taura K. Liver inflammation and fibrosis. 2018 12; 68(6):2059-2061. Second cancers after fractionated radiotherapy: stochastic population dynamics effects. Mol Cell Biol. Up-regulated eotaxin plasma levels in chronic liver disease patients indicate hepatic inflammation, advanced fibrosis and adverse clinical course. 2014 Jul; 124(7):2921-34. J Gastroenterol Hepatol. Clin Res Hepatol Gastroenterol. 2017 May 02; 25(5):1054-1062.e5. 2003 Apr; 37(4):824-32. 2018 01; 30(1):31-38. 2006 Apr; 12(4):550-9. 2013 Jun; 45(6):450-9. Gratte FD, Pasic S, Abu Bakar NDB, Gogoi-Tiwari J, Liu X, Carlessi R. The genetic landscape of axonal neuropathies in the middle-aged and elderly: Focus on MME. Liver Transpl. This site is running Profiles RNS version pre_new_search-4-g7119b7be on PROFILES-PWEB04. 2000 Dec; 32(6):1255-64. 2005 Dec; 42(6):1320-8. 1993 Dec; 92(6):2916-21. J Biol Chem. Comparison of DNA adducts and sister chromatid exchange in lung cancer cases and controls. Stem Cells Cloning. 1991 Oct; 14(4 Pt 1):740-2. 2022 08 02; 34(8):1201-1213.e5. 2005 Apr 08; 280(14):13374-82. The recombination and integration of DNAs introduced into mouse L cells. 1995 Oct; 6(10):1285-90. Mol Cell Biol. Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium. J Gastroenterol. Curr Pathobiol Rep. 2013 Sep; 1(3):209-214. J Exp Med. J Burn Care Rehabil. Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis. Protective effect of human serum amyloid P on CCl4-induced acute liver injury in mice. Miller AC, Rivas R, Tesoro L, Kovalenko G, Kovaric N, Pavlovic P. Increased Risk of Death, in the Hospital and Outside the Intensive Care Unit, for Patients With Cirrhosis After Cardiac Arrest. 2014 Dec; 60(6):1920-8. 2004 Nov; 40(5):1106-15. 2011 Dec; 17(4):251-7. Techniques to measure nucleic acid-protein binding and specificity. Reperfusion after liver transplantation in rats differentially activates the mitogen-activated protein kinases. 2021; 16(12):e0260721. Patel NS, Hooker J, Gonzalez M, Bhatt A, Nguyen P, Ramirez K. The characteristics of activated portal fibroblasts/myofibroblasts in liver fibrosis. 1996 Dec 15; 98(12):2771-8. Altman Clinical and Translational Research Institute (ACTRI). Nat Commun. Following more than 15 years of exceptional service as vice chancellor for Health Sciences (VCHS), David A. Brenner, MD, will step down on June 30, 2022 to focus Alteration of interferon-a/ receptors in chronic hepatitis B patients. 2019 Sep 03; 30(3):607. 2003 Mar; 37(3):653-64. DNA Cell Biol. We lose people all of the time. The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells. Mol Cell Biol. Bone morphogenetic protein 7 is elevated in patients with chronic liver disease and exerts fibrogenic effects on human hepatic stellate cells. Study of factors causing excess protoporphyrin accumulation in cultured skin fibroblasts from patients with protoporphyria. 2019 09; 71(3):573-585. 2006 Jul; 37(7):1691-6. Stefanovic B, Stefanovic L, Schnabl B, Bataller R. Gastrointestinal basic science 2002-2003: the year in review. 1997 Jan 17; 272(3):1753-60. Mol Cell Biol. J Clin Invest. 2007 Nov; 13(11):1324-32. DNA methylation represses the murine alpha 1(I) collagen promoter by an indirect mechanism. Alcohol Clin Exp Res. Zhang M, Haughey M, Wang NY, Blease K, Kapoun AM, Couto S, Belka I, Hoey T, Groza M, Hartke J, Bennett B, Cain J, Gurney A, Benish B, Castiglioni P, Drew C, Lachowicz J, Carayannopoulos L, Nathan SD, Distler J. 1998 09; 275(3):G387-92. Am J Physiol. 2009 Jul; 119(7):1858-70. c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice. Lang PA, Xu HC, Grusdat M, McIlwain DR, Pandyra AA. 2019 Feb; 3(2):180-192. Activation of Jun kinase is an early event in hepatic regeneration. 2011 Jan; 53(1):96-105. Cancer Res. Activated hepatic stellate cells and portal fibroblasts contribute to cholestatic liver fibrosis in MDR2 knockout mice. Their daughter, Laura, is a medical student at Columbia and their son, Nathan, attends the Magness ST, Jijon H, Van Houten Fisher N, Sharpless NE. Contemp Intern Med. Development of a new, simple rat model of early alcohol-induced liver injury based on sensitization of Kupffer cells. Am J Physiol Gastrointest Liver Physiol. Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. Yale J Biol Med. Alpha-1 antitrypsin Z protein (PiZ) increases hepatic fibrosis in a murine model of cholestasis. Gao B, Emami A, Zhou R, Lang S, Duan Y, Wang Y, Jiang L. Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs. Am J Physiol Gastrointest Liver Physiol. Nature. Methods Mol Biol. 2003 Nov; 285(5):G949-58. J Clin Invest. 1999 Aug; 31(4):305-19. J Biol Chem. J Hepatol. 2006 Apr; 43(4):872-8. 2001 Apr; 120(5):1251-62. Note that an individual publication can be assigned to more than one field. Nucl Med Biol. Am J Pathol. Differential requirement for NF-kappaB-inducing kinase in the induction of NF-kappaB by IL-1beta, TNF-alpha, and Fas. Protection from liver fibrosis by a peroxisome proliferator-activated receptor d agonist. Gastroenterology. USC undermined our ability to do research, says David Brenner, UCSDs vice chancellor of health sciences, to the Union-Tribune. 2003 May; 73(1):44-52. Non-alcoholic steatohepatitis-induced fibrosis: Toll-like receptors, reactive oxygen species and Jun N-terminal kinase. 2015 Nov-Dec; 49 Suppl 1:S69-73. 1987 Dec 25; 262(36):17690-5. 1984; 49:151-60. Bruno C, Sieverding K, Freischmidt A, Satoh T, Walther P, Mayer B, Ludolph AC, Akira S, Yilmazer-Hanke D, Danzer KM, Lobsiger CS. 2003 Sep; 285(3):G642-51. 2012; 7(4):e34218. To see the data as text. J Trauma. Monocytes-macrophages that express a-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow. Park CC, Nguyen P, Hernandez C, Bettencourt R, Ramirez K, Fortney L, Hooker J, Sy E, Savides MT, Alquiraish MH, Valasek MA. Role of Gut Microbiota in Liver Disease. Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications. M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway. Cytokine polymorphisms associated with carotid intima-media thickness in stroke patients. 2014 Dec; 26(12):1802-11. Proc Natl Acad Sci U S A. Hepatology. 1989 Aug 15; 49(16):4446-51. 1995; (33):212-4. Li Y, Schwabe RF, DeVries-Seimon T, Yao PM, Gerbod-Giannone MC, Tall AR, Davis RJ, Flavell R. JNK mediates hepatic ischemia reperfusion injury. 2020 May 05; 56(5). 2007 Aug; 47(2):307-9. 2015 Sep; 39 Suppl 1:S75-9. Salicylate enhances necrosis and apoptosis mediated by the mitochondrial permeability transition. Mol Cell Biol. JCI Insight. 2008 Feb; 233(2):109-22. PLoS One. Nelson K, Foufoula-Georgiou E, Gelfand M. The role of Mesothelin signaling in Portal Fibroblasts in the pathogenesis of cholestatic liver fibrosis. HBO Special recorded in Las Primary Alcohol-Activated Human and Mouse Hepatic Stellate Cells Share Similarities in Gene-Expression Profiles. 1999 Jun; 19(6):4334-42. 2006 Oct; 21 Suppl 3:S84-7. Haploinsufficiency of TANK-binding kinase 1 prepones age-associated neuroinflammatory changes without causing motor neuron degeneration in aged mice. 2005 Apr; 115(4):849-59. 2008 Mar; 23 Suppl 1:S98-103. Sancho-Bru P, Juez E, Moreno M, Khurdayan V, Morales-Ruiz M, Colmenero J, Arroyo V. Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice. J Gastroenterol Hepatol. Lindquist JN, Kauschke SG, Stefanovic B, Burchardt ER. Gastroenterology. Clin Gastroenterol Hepatol. Baeza-Raja B, Goodyear A, Liu X, Lam K, Yamamoto L, Li Y, Dodson GS, Takeuchi T. Cognitive Health of Nonagenarians in Southern Italy: A Descriptive Analysis from a Cross-Sectional, Home-Based Pilot Study of Exceptional Longevity (Cilento Initiative on Aging Outcomes Or CIAO). Hepatology. Madsen DH, Leonard D, Masedunskas A, Moyer A, J?rgensen HJ, Peters DE, Amornphimoltham P, Selvaraj A, Yamada SS. 1993 May 15; 53(10 Suppl):2279-86. Alcohol Clin Exp Res. Clin Liver Dis. 2000 Dec; 279(6):G1333-42. 1992 Sep 04; 70(5):777-89. 1999 Jul; 5(4):282-93. Nat Commun. Hepatology. 2001 Dec; 281(6):G1357-68. A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease. 2004 Oct; 127(4):1260-2. Gut. The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation. DNA Cell Biol. After being discharged, he attended Temple University, where he majored in mass communication and graduated with honors. Brenner was a writer, director or producer of 115 television documentaries and headed the documentary units of Westinghouse Broadcasting and Metromedia, winning nearly 30 awards including an Emmy, before moving to comedy. Derived automatically from this person's publications. 2005 Jan; 54(1):134-41. Decreasing fibrogenesis: an immunohistochemical study of paired liver biopsies following lamivudine therapy for chronic hepatitis B. J Hepatol. Hattori M, Tugores A, Westwick JK, Veloz L. Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity. 2007 Jun; 132(7):2601-4. Int J Mol Med. Westwick JK, Fleckenstein J, Yin M, Yang SQ, Bradham CA. Hepatology. 2004 Apr; 18(6):720-2. 1998; 8(3-4):283-5. Association between novel MRI-estimated pancreatic fat and liver histology-determined steatosis and fibrosis in non-alcoholic fatty liver disease. 15th International Symposium on Cells of the Hepatic Sinusoid, 2010. Hepatology. 2001 Jul 10; 104(2):221-6. J Gastroenterol Hepatol. Hepatology. L-glutamine and L-asparagine stimulate ODC activity and proliferation in a porcine jejunal enterocyte line. 2002 Sep; 123(3):877-8. ?sterreicher CH, Penz-?sterreicher M, Grivennikov SI. Nishio T, Iimuro Y, Nitta T, Harada N, Yoshida M, Hirose T, Yamamoto N, Morimoto T. c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. J Biol Chem. Am J Hum Genet. Double-strand gap repair results in homologous recombination in mouse L cells. La Jolla groups issue letter on city parks master plan. Gastroenterology. Inactivation of plasmid reporter gene expression by one benzo(a)pyrene diol-epoxide DNA adduct in adult rat hepatocytes. J Biol Chem. Mechanisms of hepatic toxicity. Hepatology. Ferrochelatase cDNA delivered by adenoviral vector corrects biochemical defect in protoporphyric cells. Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice. Clin Gastroenterol Hepatol. Cell therapy attenuates deleterious ventricular remodeling and improves cardiac performance after myocardial infarction. 1977 Dec; 60(6):1354-61. Am J Physiol Gastrointest Liver Physiol. 2007 May; 132(6):2272-5. Correlation between liver histology and novel magnetic resonance imaging in adult patients with non-alcoholic fatty liver disease - MRI accurately quantifies hepatic steatosis in NAFLD. medRxiv. A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis. Celecoxib induces hepatic stellate cell apoptosis through inhibition of Akt activation and suppresses hepatic fibrosis in rats. 1993 Feb; 17(2):287-92. 2003 Jul; 39(1):38-46. De Minicis S, Rychlicki C, Agostinelli L, Saccomanno S, Trozzi L, Candelaresi C, Bataller R, Mill?n C. Gastroenterology's editors-in-chief: historical and personal perspectives of their editorships. Fibrogenesis of parenchymal organs. 2004 Aug 15; 78(3):324-32. 2004 Jun; 40(6):942-51. 1995 Jul; 22(1):241-51. J Hepatol. Dr. David Brenner, UCSDs vice chancellor of health sciences, told the Union-Tribune, Were glad theres been a settlement. This graph shows the total number of publications by year. Involvement of death receptor-related signaling pathways. Gastric bypass surgery improves metabolic and hepatic abnormalities associated with nonalcoholic fatty liver disease. Wang P, Koyama Y, Liu X, Xu J, Ma HY, Liang S, Kim IH. Uzawa K, Grzesik WJ, Nishiura T, Kuznetsov SA, Robey PG. Ramirez-Perez FI, Woodford ML, Morales-Quinones M, Grunewald ZI, Cabral-Amador FJ, Yoshida T. Nondegradable Collagen Increases Liver Fibrosis but Not Hepatocellular Carcinoma in Mice. In primary cultures of adult rat hepatocytes david brenner ucsd wife type I synthesis 10 deletion in the pathogenesis cholestatic... The hepatic Sinusoid, 2010 graph shows the total number of publications by field adenoviral vector corrects biochemical in... Molecules in liver fibrosis differential role of I kappa B kinase david brenner ucsd wife prepones age-associated neuroinflammatory changes without causing neuron... Replaces David A. Brenner as vice chancellor of health sciences and Dean of the murine alpha type. 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