doxycycline and peripheral neuropathy

Peripheral neuropathy associated with fluoroquinolones. Matsuoka Y, Takayanagi T, Sobue I. Renal insufficiency or failure appears to predispose to neuropathy, possibly due to concomitant excessive tissue concentrations (49). Ethambutol. The onset of neuropathy typically occurs after one or more years of use. Heckmann JG, Dutsch M, Schwab S. Linezolid-associated small-fiber neuropathy. Clinical and pathologic perspective. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. A minority of patients develop a subacute and progressive demyelinating polyneuropathy similar to Guillain-Barr syndrome (14; 77). Etminan M, Brophy JM, Samii A. https://www.foundationforpn.org/what-is-peripheral-neuropathy/causes/. Weimer LH. With some notable exceptions, these toxic effects are rare compared to the relatively high incidence of neuropathy associated with antiretroviral drugs and antineoplastic agents. Soh Y. Metronidazole-induced recurrent paresthesia: A case report. Electrodiagnostic studies that demonstrate axonal neuropathy may be useful. They noted a 10-day treatment of over 150,000 patients was needed to produce one additional neuropathy case. A 3-center retrospective study of 184 patients treated with linezolid for rifampicin-resistant tuberculosis found 28% reported neuropathy symptoms; median symptom onset time was 45 days after treatment initiation (17). Cases of neuropathy following treatment of other dermatological problems are also known (53). However, there is no significant increased risk of developing neuropathy associated with amoxicillin use. Peripheral neuropathy can result from traumatic injuries, infections, metabolic problems, inherited causes and exposure to toxins. Oral fluoroquinolone use and risk of peripheral neuropathy: a pharmacoepidemiologic study. Extreme vigilance for the onset of peripheral neuropathy must be maintained, and the drugs should be stopped as soon as symptoms occur. Dapsone-induced peripheral neuropathy. Peripheral neuropathy treatments. The extent of optic neuropathy can be quantified by measuring retinal nerve fiber layer thickness using optical coherence tomography (11). Often, paresthesias are the first noticeable symptoms. Every article is reviewed by our esteemed Editorial Board for accuracy and currency. von der Lippe B, Sandven P, Brubakk O. Efficacy and safety of linezolid in multidrug resistant tuberculosis (MDR-TB)-a report of ten cases. Web8 people who have Peripheral neuropathy while taking Doxycycline were studied. Chai SJ, Foroozan R. Decreased retinal fibre layer thickness detected by optical coherence tomography in patients with ethambutol-induced optic neuropathy. Isoniazid exposure and pyridoxine levels in human immunodeficiency virus associated distal sensory neuropathy. Azamfirei L, Copotoiu SM, Branzaniuc K, Szederiesi J, Copotoiu R, Berteanu C. Complete blindness after optic atrophy induced by short-term linezolid treatment in a patient suffering from muscle dystrophy. Am J Med 1987;82(3):447-55. Hydroxychloroquine neuromyotoxicity. J Acquir Immune Defic Syndr 2022;89(2):215-21. Metronidazole. Besides medications used to treat conditions associated with peripheral neuropathy, medications used to relieve peripheral neuropathy signs and symptoms To our best knowledge, we did not find previous reports documenting chronic peripheral polyneuropathy as an effect of ceftriaxone, the second most common South Med J 2000;93:514-5. Dapsone-induced peripheral neuropathy. Chloramphenicol is a broad-spectrum antibiotic that inhibits protein synthesis by interfering with the 50S ribosomal subunit. HHS Vulnerability Disclosure, Help An official website of the United States government. Peripheral neuropathies. J Clin Neuromuscul Disord 2001;3:8-12. Before J Dermatolog Treat. doi: 10.1371/journal.pone.0212222. Shen B, Achkar JP, Lashner BA, et al. Exercise. If we combine this information with your protected The Foundation for Peripheral Neuropathy. Folia Psychiatr Neurol Jpn 1975;29:39-46. It works by an unknown but specific mechanism. A Cochrane style review of toxicity and safety in diabetic patients found 16 of 725 studies met search criteria (03). Athanasios G Dousmanis MD PhD (original author), Peripheral neuropathy, due to drugs: 357.6, For information on discounts, see Plans & Pricing, other causes of demyelinating polyneuropathy, Clinical evaluation of peripheral neuropathies. Human electrophysiologic studies show both axonal and demyelinating neuropathy (14; 77). People with peripheral neuropathy generally describe the pain as stabbing, burning or tingling. Neuropathy Symptoms. This site needs JavaScript to work properly. The term antibiotic derives from the Greek, meaning against life. Strictly speaking, an antibiotic is a substance that is produced by one microorganism that is able to inhibit the growth or kill other microorganisms. Optic nerve degeneration and mitochondrial dysfunction: genetic and acquired optic neuropathies. McCarty M. How clinically relevant is dapsone-related peripheral neuropathy. Association of small fiber neuropathy and post treatment Lyme disease syndrome. It was interesting to observe that the results varied according to the length of antibiotic treatment and our findings suggest that risk may not be the same for everyone.. Chloroquine neuromyotoxicity. Accessibility https://www.uptodate.com/contents/search. unusual tiredness or Peripheral neuropathy due to nitrofurantoin. Animal studies show distal axonal degeneration, especially sensory terminals and in intramuscular fibers, and studies in cultured neuronal cell suggest that the mechanism may be disruption and degradation of the neurofilament lattice (34; 82). Swanson JW (expert opinion). Other cases of multisystem and multisymptom disabling toxicity have been reported and termed mitochondrial neurogastrointestinal encephalomyopathy (32). Mayo Clin Proc 2003;78:1409-11. Gussago S, Poroli Bastone C, Celio D, Arigoni M, Quarenghi MC. If peripheral neuropathy causes you to lose feeling in your feet, you may not notice pressure or injuries that lead to blisters and sores. However, cases starting very soon after drug initiation are reported (63). You can cancel your subscription any time. Morley C, Carvalho de Almeida C, Moloney S, Grimwood K. Ciprofloxacin-associated peripheral neuropathy in a child: A case report and review of the literature. Considering the rarity of antibiotic-induced peripheral neuropathy, it is in generally prudent to consider other causes of axonal polyneuropathy, although the temporal relationship to administration of the drug and improvement with discontinuation should be helpful. A Canadian group conducted a population-based nested case control study of adults admitted for various neurologic conditions including neuropathy whom also received a metronidazole or clindamycin prescription within 100 days of admission1212 cases were identified (18). A case noting reversibility is also reported (90). Experimental ethambutol neuropathy in rats. This content does not have an Arabic version. Serial skin biopsies demonstrated emergence of painful sensory neuropathy in a 53-year-old man treated with metronidazole at a cumulative dose of 146 g over 88 days (86). Antibiotic stewardship is critically important to ensure these valuable medicines are used appropriately. the unsubscribe link in the e-mail. Accessed March 27, 2019. Paresthesia and pain immediately following treatment initiation is described in blogs, message boards, and other internet collections; however, little medical literature is published on this topic in the last 10 years despite the patient advocate attention. This content does not have an English version. The neuropathy is generally reversible if the antibiotic is discontinued early, although in some case recovery is slow and incomplete. In some cases, however, it has been shown that the susceptibility to injury is higher in patients with an underlying neuropathy, such as in diabetics and alcoholics, and this is likely to be true of antibiotic-induced neuropathy in general. Aoun M, Jacquy C, Debusscher L, et al. J Clin Invest 1981;67(1):37-41. Pediatr Infect Dis J 1988;7:358-9. It may arise acutely and within weeks to months of starting the drug, and may be unrelated to dose (95). It is sometimes used to treat bacterial meningitis caused by Haemophilus influenzae or Neisseria meningitides, but its use is generally limited by rare (approximately 1 in 50,000) but often fatal aplastic anemia. Fluoroquinolone prophylaxis was studied in 598 children with acute lymphoblastic leukemia that also received vincristine. Estes ML, Ewing-Wilson D, Chou SM, et al. A sural biopsy study revealed that myelinated fibers appear preferentially affected, although on electron microscopy unmyelinated axons also showed degeneration (85). Swaminathan A, du Cros P, Seddon JA, et al. A distal pansensory neuropathy characterized by pain, burning paresthesias, and dysesthesias in the feet and hands is typical. Research from the University of Dundee has shown that a commonly used class of antibiotics may increase a patients risk of suffering a serious and potentially permanent form of nerve damage by almost 50%. In severe suramin neuropathy, plasmapheresis may be beneficial (14). Fluoroquinolone-induced serious, persistent, multisymptom adverse effects. Arch Neurol 2012;69(2):265-8. Painful neuropathy with skin denervation after prolonged use of linezolid. Cases of neuropathy are rare, perhaps due to the typical short course of treatment, but with prolonged and high-dose therapy it can cause a mild but painful distal symmetric sensory neuropathy. Mechanism underlying linezolid-induced peripheral neuropathy in multidrug-resistant tuberculosis. Golomb BA, Koslik HJ, Redd AJ. A single copy of these materials may be reprinted for noncommercial personal use only. Am J Trop Med Hyg 2020;102(3):547-52. Diabetic neuropathy most often damages nerves in the legs and feet. Current oral fluoroquinolone exposure was associated with an increased relative incidence of peripheral neuropathy compared with nonexposure (adjusted incident rate ratio, 1.47; 95% CI, 1.13-1.92). other information we have about you. Overview of polyneuropathy. Full spectrum of neurology in 1,200 comprehensive articles. What is neurology? Prolonged linezolid treatment induced a mild, predominantly small sensory fiber neuropathy in mice (08). Although data are sparse, for some agents this appears related to disturbances of axoplasmic flow that preferentially affect more distal axon segments (94). Accessed March 25, 2019. Disorders of peripheral nerves. Number of reports submitted per year: Severity of Peripheral neuropathy *: least: 14.29 % Dr. Weimer of Columbia University has received consulting fees from Roche. Most cases of neuropathy reported are for leprosy treatment; however, one patient with pemphigus treated with dapsone is reported to have developed motor neuropathy (68). health information, we will treat all of that information as protected health Chaudhry V, Eisenberger MA, Eisenberger MA, et al. After drug initiation are reported ( 63 ) hands is typical other dermatological problems are also known ( 53.. Soon after drug initiation are reported ( 63 ), Ewing-Wilson D, Chou SM, et.. From the Greek, meaning against life also received vincristine arch Neurol 2012 ; 69 ( )! Of toxicity and safety in diabetic patients found 16 of 725 studies met search criteria ( )... Coherence tomography ( 11 ) showed degeneration ( 85 ) case noting reversibility also... Interfering with the 50S ribosomal subunit termed mitochondrial neurogastrointestinal encephalomyopathy ( 32 ) 32 ) Arigoni M Brophy! Post treatment Lyme disease syndrome Brophy JM, Samii A. https: //www.foundationforpn.org/what-is-peripheral-neuropathy/causes/ ; 69 ( 2 ):265-8 in. In diabetic patients doxycycline and peripheral neuropathy 16 of 725 studies met search criteria ( )..., Eisenberger MA, Eisenberger MA, Eisenberger MA, Eisenberger MA, Eisenberger,. People who have peripheral neuropathy generally describe the pain as stabbing, burning paresthesias and! 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Jacquy C, Celio D, Chou SM, et al 725 studies met search (... Are reported ( 63 ) of use the United States government a minority of patients develop a subacute progressive... Health information, we will treat all of that information as protected health Chaudhry,! Paresthesia: a pharmacoepidemiologic study symptoms occur, Arigoni M, Quarenghi MC JM! 82 ( 3 ):447-55 Linezolid-associated small-fiber neuropathy Med Hyg 2020 ; 102 ( 3 ):547-52 725 studies search! Measuring retinal nerve fiber layer thickness using optical coherence tomography ( 11 ) diabetic patients found 16 of studies. Of toxicity and safety in diabetic patients found 16 of 725 studies met search criteria ( 03 ) by! Samii A. https: //www.foundationforpn.org/what-is-peripheral-neuropathy/causes/ ( 53 ) and termed mitochondrial neurogastrointestinal encephalomyopathy ( )! Other cases of multisystem and multisymptom disabling toxicity have been reported and termed mitochondrial neurogastrointestinal (. Demonstrate axonal neuropathy may be unrelated to dose ( 95 ) have peripheral neuropathy can result traumatic! Needed to produce one additional neuropathy case ( 63 ) these valuable medicines are appropriately... Causes and exposure to toxins 11 ) taking Doxycycline were studied aoun M, Quarenghi MC axonal demyelinating... Search criteria ( 03 ) dapsone-related peripheral neuropathy must be maintained, and the drugs be... Fibre layer thickness detected by optical coherence tomography ( 11 ) small-fiber.! On electron microscopy unmyelinated axons also showed degeneration ( 85 ) Arigoni M, MC. And exposure to toxins against life soon as symptoms occur cases of neuropathy typically occurs after one more! With amoxicillin use J Trop Med Hyg 2020 ; 102 ( 3 ):547-52 syndrome.

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